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Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Identifieur interne : 002454 ( Main/Exploration ); précédent : 002453; suivant : 002455

Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Auteurs : SHIMING LI [États-Unis] ; Min-Hsiung Pan [Taïwan] ; Ching-Shu Lai [Taïwan] ; Chih-Yu Lo [États-Unis] ; Slavik Dushenkov [États-Unis] ; Chi-Tang Ho [États-Unis]

Source :

Bioorganic & medicinal chemistry [ 0968-0896 ] ; 2007.

RBID : Pascal:07-0450699

Descripteurs français

Pascal (Inist)
- Isolement, Synthèse chimique, Cytotoxicité, Lignée HL60, Lignée cellulaire, Citrus sinensis, Plante médicinale, Ether, Cellule tumorale, Phénols, Apoptose, Anticarcinogène, Flavone dérivé, Pelure, Anticancéreux, Relation structure activité, Pharmacognosie, In vitro, Homme, Flavonoïde, Origine végétale, Fruit, Nobiletine dérivé.
Wicri :
- topic : Plante médicinale, Homme, Fruit.

English descriptors

KwdEn :
- Anticarcinogen, Antineoplastic agent, Apoptosis, Cell line, Chemical synthesis, Citrus sinensis, Cytotoxicity, Ether, Flavone derivatives, Flavonoid, Fruit, HL60 cell line, Human, In vitro, Isolation, Medicinal plant, Peel, Pharmacognosy, Phenols, Plant origin, Structure activity relation, Tumor cell.

Abstract

Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticarcinogen</term>
<term>Antineoplastic agent</term>
<term>Apoptosis</term>
<term>Cell line</term>
<term>Chemical synthesis</term>
<term>Citrus sinensis</term>
<term>Cytotoxicity</term>
<term>Ether</term>
<term>Flavone derivatives</term>
<term>Flavonoid</term>
<term>Fruit</term>
<term>HL60 cell line</term>
<term>Human</term>
<term>In vitro</term>
<term>Isolation</term>
<term>Medicinal plant</term>
<term>Peel</term>
<term>Pharmacognosy</term>
<term>Phenols</term>
<term>Plant origin</term>
<term>Structure activity relation</term>
<term>Tumor cell</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Isolement</term>
<term>Synthèse chimique</term>
<term>Cytotoxicité</term>
<term>Lignée HL60</term>
<term>Lignée cellulaire</term>
<term>Citrus sinensis</term>
<term>Plante médicinale</term>
<term>Ether</term>
<term>Cellule tumorale</term>
<term>Phénols</term>
<term>Apoptose</term>
<term>Anticarcinogène</term>
<term>Flavone dérivé</term>
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<term>Anticancéreux</term>
<term>Relation structure activité</term>
<term>Pharmacognosie</term>
<term>In vitro</term>
<term>Homme</term>
<term>Flavonoïde</term>
<term>Origine végétale</term>
<term>Fruit</term>
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<front><div type="abstract" xml:lang="en">Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.</div>
</front>
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Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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